Table of Contents


Principles and Evolution of Actin Nucleator Complexes

Actin is a structural protein found in all eukaryotic cells (cells with nucleus), that builds in the cells dynamic filaments to stabilize the outer cell shape and to perform intracellular transports. The Actin nucleation allows the cell to adapt quickly their shape and stiffness to environmental changes.

An system is being developed that supports the analysis of Actin nucleation under an evolutionary perspective.

Accomplished Work

Consortium

University of Würzburg, University Hospital Regensburg, University Hospital Münster, University Hospital Bonn, University Medical Center Göttingen, University Hospital Jena, University Hospital Heidelberg, University Hospital Hamburg-Eppendorf, Hannover Medical School, Max Planck Instituteof Biochemistry (Martinsried), Max Planck Institute of Neurobiology (Martinsried), EMBL European Molecular Biology Laboratory (Heidelberg), IMBA Institute of Molecular Biotechnology (Vienna).

German Research Foundation (DFG) Priority program (SPP) 1464

GEPAT - Genome Expression Pathway Analysis Tool

Microarray gene expression data allows the functionality of living cells to be analyzed. With their help, the transcription activity of a cell and thus the activity of specific genes can be measured quantitatively. For example, the activity of genes in healthy and diseased tissues can be compared, and the causes of diseases determined.

The enormous amount of data in the use of microarrays is the major challenge on their analysis. An integrated system was developed that supports the analysis and visualization of microarray gene expression data under the genomic, the proteomic and the metabolic point of view.

Accomplished Work

German Research Foundation (DFG) Grant SCHU 2352/2-1